Fast Implementation for Normal Mixed Effects Models With Censored Response
نویسندگان
چکیده
منابع مشابه
Efficient hybrid EM for linear and nonlinear mixed effects models with censored response
Medical laboratory data are often censored, due to limitations of the measuring technology. For pharmacokinetics measurements and dilution-based assays, for example, there is a lower quantification limit, which depends on the type of assay used. The concentration of HIV particles in the plasma is subject to both lower and upper quantification limit. Linear and nonlinear mixed effects models, wh...
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HIV RNA viral load measures are often subjected to some upper and lower detection limits depending on the quantification assays. Hence, the responses are either left or right censored. Linear (and nonlinear) mixed-effects models (with modifications to accommodate censoring) are routinely used to analyze this type of data and are based on normality assumptions for the random terms. However, thos...
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Often in biomedical studies, the routine use of linear mixed-effects models (based on Gaussian assumptions) can be questionable when the longitudinal responses are skewed in nature. Skew-normal/elliptical models are widely used in those situations. Often, those skewed responses might also be subjected to some upper and lower quantification limits (QLs; viz., longitudinal viral-load measures in ...
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ژورنال
عنوان ژورنال: Journal of Computational and Graphical Statistics
سال: 2009
ISSN: 1061-8600,1537-2715
DOI: 10.1198/jcgs.2009.07130